Marta Artola
Assistant Professor Medical Biochemistry,
Leiden Institute of Chemistry
My group rationally develops biochemical tools including substrates, inhibitors and protein degraders for glyco-processing enzymes. We apply these tools to investigate biological processes and develop therapeutic strategies.
m.e.artola@lic.leidenuniv.nl
https://www.universiteitleiden.nl
Organic chemistry, chemical biology, and medical biochemistry
Noortje de Haan
Assistant Professor Tissue Glycomics,
Center for Proteomics and Metabolomics, Leiden University Medical Center
Inspired by the huge impact that small changes in glycan structures can have on human health, my group is dedicated to developing the tools to study glycosylation in human tissues in health and disease. Our key technologies are nano-liquid chromatography coupled to mass spectrometry (nanoLC-MS) and mass spectrometry imaging (MSI).
n.de_haan@lumc.nl
https://cpm.lumc.nl
Glyco MSI; Released glycan profiling cells and tissues
Alan Moran
Sr. Scientist, Johnson & Johnson Innovative Medicine
linkedin.com/in/moranalan
Glycoconjugates, vaccines, glycosylation characterization
Manfred Wuhrer
Professor of Proteomics and Glycomics
Center for Proteomics and Metabolomics, Leiden University Medical Center
My group develops and applies mass spectrometric techniques that allow protein glycosylation analysis at high sensitivity and often in a high-throughput fashion. These methods are applied to characterize e.g. immunoglobulin glycosylation in autoimmunity, infection and vaccination, but also to characterize the structure and function of the glycosylation of biopharmaceuticals.
m.wuhrer@lumc.nl
https://cpm.lumc.nl
Antibodies, biopharmaceuticals, glycosylation profiling
Zach Armstrong
Assistant Professor
Leiden Institute of Chemistry
Dr. Armstrong’s research spans the disciplines of Chemistry and Biology with particular focus on carbohydrate modifications and how they relate to both disease states and host-pathogen interactions. His research group focuses on the structural biology of modifying enzymes, developing new tools for profiling carbohydrate modifying enzymes and exploiting these tools to develop new therapeutics.
z.w.b.armstrong@lic.leidenuniv.nl
armstrongchembio.org
Stuctural Biology, Enzymology, Biochemical and biological tools, Chemistry
Yuri van der Burgt
Associate professor
Center for Proteomics and Metabolomics, Leiden University Medical Center
My research is focused on identification and quantification of protein- and glycobiomarkers in cancer in general, and in pancreatic cancer in specific. Large clinical cohorts are used for discovery and evaluation studies using a mature toolbox with glycomic and glycoproteomic strategies based on mass spectrometry
y.e.m.van_der_burgt@lumc.nl
Analytics, Clinical chemistry
Willianne Hoepel
Junior principal investigator
Department of Immunology, Leiden University Medical Center
Our research focuses on antibody glycosylation in the nasal cavity, particularly in the context of respiratory viral infections. We run clinical studies to explore these immune responses. Furthermore, we use various in-vitro models, including organoids, to investigate how variations in antibody glycosylation affect their function
j.w.hoepel@lumc.nl
immunology.lumc.nl/willianne-hoepel
Biomedical applications, Antibodies, viral infections, functional assays.
Ilaria Poledri
Co-founder & CSO
ExCulture
ExCulture utilises a mixed culture fermentation bioprocess to manufacture a safer, animal free heparin alternative. Within this bioprocess, self-assembly of microorganisms release sulfated glycosaminoglycans in the extracellular matrix, such as heparin and other biomedically relevant compounds, which ExCulture is isolating and testing for its therapeutic potential.
ilaria@exculturebiotech.com
exculturebiotech.com
Biomedical applications, Molecular biology
Hans Ulrich Scherer
Professor of Rheumatology
Leiden University Medical Center
Our aim is to understand the biology of autoreactive B cells in the context of autoimmune diseases. To this end, we study the modification of autoantibodies/B cell receptors by glycans and the impact of such modifications on the function and characteristics of autoreactive B cells and the autoantibodies they secrete.
h.u.scherer@lumc.nl
lumc.nl/hu-scherer
Biomedical applications, Molecular biology
Bruno Guigas
Associate Professor
Leiden University Center for Infectious Diseases
My research group is working on systemic immunometabolism, studying the immune-mediated regulation of metabolic homeostasis in the context of obesity, MASLD/MASH, type 2 diabetes and infection. One of our project is aiming to investigate the role of glycans in the crosstalk between metabolic and immune cells within metabolic organs, and how changes in protein glycosylation might affect organ-specific functions in both cardiometabolic diseases and response to parasitic infections.
b.g.a.guigas@lumc.nl
lumc.nl/bruno-guigas
Biochemical and biological tools, Immunometabolism